Abstract

 

Introduction: Integrins have recently been proposed as having a major role in endometrial receptivity. The aim of this study was investigation of different patterns of integrin expression during the normal endometrial oestrous cycle.

 

Material and method: Stages of estrous cycle were determined in mice by analysis of vaginal smears then they were sacrificed by cervical dislocation and the tissues were obtained from the middle 1/3 part of their uterine horns immediately and processed for studies immunostaning.

 

Result: Integrins was maximally expressed in the metestrus phase in endometrum. Integrin beta 3, alpha 4 and beta 1 were detected in luminal and glandular epithelial but alpha v was detected only in glandular epithelial. Integrins of alpha v and beta 3 in the stroma were seen too.

 

Conclusion: Expression of integrins in metestrus phase of oestrous cycle in mouse around the time of the implantation window suggest a role for these proteins in endometrial function and implantation.

 

Key words; Endometrium , mouse, integrin, immunohistochemistry, implantation